Keywords:

Medicinal plants used for neurological and mental disorders in Navarra and their validation from official sources. Prior to the study, permission was granted from the leadership of GHAFTRAM and all participants duly signed informed consents. Sign up here as a reviewer to help fast-track new submissions.

was the plant with the highest frequency of mention (mentioned 7 times; Figure 3). The present study constitutes a good basis for further phytochemical and pharmacological research of C. nobile, J. glutinosa and S. chamaecyparissus, which could be of interest in the design of new inexpensive, effective and safe drugs. While clinical integration of TAMs may be beneficial, at present, this should be approached with caution due to the inadequacy of studies exploring their efficacy and safety. In addition, an undergraduate program in herbal medicine which complements university training with hands-on internships at a herbal medicine research centre as well as herbal and allopathic practitioners has been established [14]. https://doi.org/10.1016/j.jep.2015.04.035.

Effects of teas prepared from the leaves on laboratory animals,”, C. A. R. D. A. Costa, D. O. Kohn, V. M. De Lima, A. C. Gargano, J. C. Flório, and M. Costa, “The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass),”, J. Leite, M. De Lourdes V. Seabra, E. Maluf et al., “Pharmacology of lemongrass (Cymbopogon citratus Stapf).

Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease. Study participants were TMPs who were all members of GHAFTRAM attending a meeting in Accra.

The Ghanaian vernacular names of the plant species are listed in Table 5. About 40.9% of the TMPs were either 50-59-year-old or 60 years and above (27.3%). Assessment of eventual toxic, hypnotic and anxiolytic effects on humans,”, M. R. Silva, R. M. Ximenes, J. G. M. da Costa, L. K. A. M. Leal, A. 2020 Aug 6;13(8):183. doi: 10.3390/ph13080183.

Herbal preparations of this plant are also used by TMPs in other African countries for the treatment of mental disorders [27] and have been shown to be relatively safe with LD50 of 17.5 g/kg [28]. This would enable the industrial-scale production and marketing of successful drug candidates following drug authority approval. Box LG 55, Legon, Accra, Ghana, Department of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, P.O. 2018, Article ID 8590381, 14 pages, 2018. https://doi.org/10.1155/2018/8590381, 1Department of Pharmacology & Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, P.O.

Of the remaining 80%, the authors highlight Chamaemelum nobile , Jasonia glutinosa , and Santolina chamaecyparissus ssp. We are grateful to the leadership of GHAFRAM for facilitating the study and the herbal practitioners who spent time participating in the study.

The most used species are Chamaemelum nobile (L.) All., Jasonia glutinosa (L.) DC., and Santolina chamaecyparissus L. ssp. The excluded delegates were not specialized in the treatment of mental and neurological diseases, as they found such patients quite difficult to manage.

Sources of knowledge and duration of practice for traditional medicine practitioners who treat mental and neurological disorders in Ghana. squarrosa for its validation.

These diseases include Parkinson’s disease, epilepsy, schizophrenia, bipolar disorder, Alzheimer’s disease and other dementias, neuroinfections, brain tumors, traumatic disorders, and cerebrovascular diseases such as stroke and migraine. R. vomitoria Afz., belonging to the family Apocynaceae, however, has been previously reported to have antipsychotic properties [16, 18] (Table 5).

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sees treated mice,”, M. M. Blanco, C. A. R. A. Costa, A. O. Freire, J. G. Santos Jr., and M. Costa, “Neurobehavioral effect of essential oil of Cymbopogon citratus in mice,”, E. A. Carlini, J. In total, 66 TMPs were interviewed: 65 and 1 from the Greater Accra and Brong-Ahafo regions, respectively.

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Amoateng P, Quansah E, Karikari TK, Asase A, Osei-Safo D, Kukuia KKE, Amponsah IK, Nyarko AK.

GHAFTRAM has members from all parts of Ghana, working together towards advancing the development of TAMs. The present study sought to address this knowledge gap by using a guided survey to document TAMs used in the treatment of mental and neurological disorders in Ghana based on traditional knowledge.

A. Olajide, S. O. While roots, fruits, flowers, stems, stem barks, whole plant of shrubs, etc. Sociodemographic characteristics of traditional medical practitioners who treat mental and neurological disorders in Ghana. 2014 Nov 18;157:268-73. doi: 10.1016/j.jep.2014.09.047. The most frequently used parts were inflorescence (39%), flowered aerial parts (16%), and aerial parts (13%), followed by inflorescence bract (8%) and leaves (7%). Most of the identified plants have been scientifically confirmed to possess neuro- and psychopharmacological properties and may serve as templates for drug development. In particular, half of the identified TAMs were analgesics, possibly suggesting that the TMPs were most often presented with patients suffering from headache, migraine, or other associated conditions. The disease burden is even more prominent in the developing world, including Ghana [3, 5, 6]. Field et al., “Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III,”, J. I.

Remarkably, R. vomitoria Afz. Conclusions: BB/J014532/1. NIH

To be included in the interview, one had to be a (a) TMP practicing in Ghana, potentially treating mental and neurological diseases directly or having some level of knowledge on products used in treating such patients or (b) registered member of GHAFTRAM willing to participate in the survey.

Data obtained from the ethnobotanical study were analyzed using the Statistical Package for Social Sciences version 22.0 for Windows.

Data indicate a high degree of plants knowledge in Navarra regarding neurological and mental disorders. Ethnopharmacological relevance: Front Pharmacol. In the present study, several plant species (32 species) used by local TMPs to treat mental and neurological disorders were reported, with most species belonging to the families Asteraceae, Apocynaceae, and Meliaceae.

For example, the antimalarial drugs Quinimax® (a combination of quinone, cinchonine, and quinidine) and Malarone® (proguanil and avoquone) are produced and marketed as synergistic complementary drugs (Bunnag et al., 1989; Fivelman et al., 2004). treatment,”, N. Khanna, M. Goswami, P. Sen, and A. Ray, “Antinociceptive action of Azadirachta indica (Neem) in mice: Possible mechanisms involved,”, A. K. Jaiswal, S. K. Bhattacharya, and S. B. Acharya, “Anxiolytic activity of, A. F. Fotso, F. Longo, P. D. D. Djomeni et al., “Analgesic and antiinflammatory activities of the ethyl acetate fraction of Bidens pilosa (Asteraceae),”, D. S. Alviano, K. F. Rodrigues, S. G. Leitão et al., “Antinociceptive and free radical scavenging activities of Cocos nucifera L. (Palmae) husk fiber aqueous extract,”, S. Naskar, U. K. Mazumder, G. Pramanik, P. Saha, P. K. Haldar, and M. Gupta, “Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of cocos nucifera l.,”, S. Rinaldi, D. O. Silva, F. Bello et al., “Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae),”, M. Gupta, U. K. Mazumder, D. Pal, S. Bhattacharya, and S. Chakrabarty, “Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa Roxb. The study objectives, method, and planned use of information were explained to the TMPs before the interviews.

Therefore, increasing TAMs-based research in Ghana would be a crucial step towards rigorous establishment of their safety, therapeutic, and adverse reaction profiles. This study was funded by the Office of Research, Innovation and Development (ORID), University of Ghana, Accra, Ghana, grant awarded to Dr. Patrick Amoateng (reference number: URF/6/ILG-002/2012-2013). In order to confirm the pharmacological validation of the uses claimed by the informants, monographs from Official International Agencies (ESCOP, Commission E, WHO and EMA) were reviewed.

Epub 2015 Apr 9. A. Osunkwo, “The anti-inflammatory and antinociceptive properties of the chloroform fraction from Phyllanthus niruri plant is mediated via the peripheral nervous system,”, M. Ahmed, H. A. Shikha, S. K. Sadhu, M. T. Rahman, and B. K. Datta, “Analgesic, diuretic, and anti-inflammatory principle from Scoparia dulcis,”, S. M. Freire, L. M. Torres, N. F. Roque, C. Souccar, and A. J. Lapa, “Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha),”, G. F. Ibironke, A. S. Umukoro, and D. C. Ajonijebu, “Central nervous system activity of the ethanol leaf extract of Sida acuta in rats,”, K. Konaté, I. H. N. Bassolé, A. Hilou et al., “Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors and limited access to standard healthcare have led to a reliance on traditional medicines.

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In this study, an ethnobotanical description of plant species used in treating mental and neurological disorders in Ghana and an update of their experimentally validated pharmacological relevance are provided. NCI CPTC Antibody Characterization Program. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso,”, J. I. Nwaiwu and P. A. Akah, “Anticonvulsant activity of the volatile oil from the fruit of tetrapleura tetraptera,”, J. Two hundred herbalists agreed to participate but sixty-six specialized in treating mental and neurological disorders were interviewed on their traditional medical practice.

Materials and Methods. Box LG 43, Legon, Accra, Ghana, Pharmacology, School of Health and Life Sciences, De Montfort University, Leicester LE1 9BH, UK, School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK, Midlands Integrative Biosciences Training Partnership, University of Warwick, Coventry CV4 7AL, UK, Department of Plant and Environmental Biology, School of Biological Sciences, College of Basic & Applied Sciences, University of Ghana, P.O. Others had reported sedative, anti-Alzheimer’s disease, motor coordination, antipsychotic, antidepressant, cognitive enhancement, and neuroprotective properties.

Among the 200 TMPs present at the GHAFTRAM meeting, 66 were included in this study. Epub 2016 Jun 4. Nine out of 46 plants (20%) and 81 of 172 uses (47%), have already been pharmacologically validated. About 36.5% had practiced for 16-20 years, while 27% had practiced for 1-5 years (Table 2).

Centella asiatica, Avena sativa, Lagenaria sicerana, Cassia tora, Cassia fistula are some of the important plants used in nervous disorders. Awe, J. M. Makinde et al., “Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark,”, K. Ilango, G. Maharajan, and S. Narasimhan, “Anti-nociceptive and anti-inflammatory activities of, R. Maiti, S. Kumar, S. Acharya, and M. Raghavendra, “Role of aqueous extract of Azadirachta indica leaves in an experimental model of Alzheimer, M. I. Akpanabiatu, I.



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